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Concept

Concept

Over the past years it has become eminently clear that many disorders have a developmental etiologic component (6). The distinctive main idea of the NEUROBID project is, therefore, that the disease initiation process even in adult neurological and psychiatric disorders may begin during early brain development and involve long-lasting changes in BBB functioning (7-9). Thus, we propose to take a developmental approach in studying the molecular mechanisms and function of the BBB in health and disease in order to devise methods to protect the BBB. In addition, there are multiple macromolecular transport systems across brain barrier interfaces that are specifically present during the various phases of brain development and detailed understanding of these systems will allow optimized targeting of large molecule delivery to the developing and adult brain.

6. Gillman MW, Barker D, Bier D, Cagampang F, Challis J, Fall C, et al. Meeting report on the 3rd International Congress on Developmental Origins of Health and Disease (DOHaD). Pediatr Res 2007;61(5 Pt 1):625-9.
7. Fatemi SH. Neuropsychiatric Disorders and Infection. 2005.
8. Glymour MM, Avendano M, Berkman LF. Is the 'stroke belt' worn from childhood? Risk of first stroke and state of residence in childhood and adulthood. Stroke 2007;38(9):2415-21.
9. Stolp HB, Dziegielewska KM. Role of developmental inflammation and blood-brain barrier dysfunction in neurodevelopmental and neurodegenerative disease. Neuropathol Appl Neurobiol 2009 in press.

 



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Funded by the European Commisssion under the grant agreement n° HEALTH-F2-2009-241778.