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Description

The Universitaetsklinikum Wuerzburg works in close cooperation with the Medical Faculty of the Universitaet Wuerzburg, one of the lading institutions of higher education in Germany. This has been confirmed by rankings carried out by national and international research organizations, international external assessment committees as well as by the German Federal and State Excellence Initiatives.

For the NEUROBID project, the research activities are allocated to the clinics and policlinics of anaesthesiology of the Universitaetsklinikum.

 

Persons

Carola Förster This e-mail address is being protected from spambots. You need JavaScript enabled to view it

The research team led by Carola Förster is centered on structure, molecules and functional properties of the blood brain barrier and its regulation in physiology and disease. The research activities have a strong focus on the role of steroid hormones on the regulation of barrier permeability, i.e. in therapy, with a focus on their effects on the expression of integral membrane proteins of the plasma membrane responsible for cell adhesion and for specific transport activities. The main model system for the analysis of the regulation of the blood brain barrier is the murine immortalised cell line cEND generated during a Marie Curie Reintegration Grant, MERG-CT510649, FP6. The laboratory of Carola Förster discovered the induction of cell adhesion molecules by steroids in epithelial cells and the cardiovascular system during her Marie Curie postdoctoral training period MCFi2000-00799 (2000 – 2003). More recent activities are focussed on the characterisation of the role of steroid hormones (estrogen, glucocorticoids) in regulation of the blood brain barrier. Within NEUROBID the partners at University of Wuerzburg offer contributions on the action of glucocorticoids on blood brain barrier integrity and transport in different developmental stages and in hypoxia/ischemia. The group will offer mainly murine and human in vitro models of the BBB, but will also perform in vivo experimental stroke experiments.

Christian Speer

Christian Speer is Chair of Paediatrics and a world-renowned expert in newborn Medicine with more than 20 years experience. He has a long-standing interest in the pathogenicity of inflammatory mechanisms in bronchopulmonary dysplasia, a neonatal lung disorder associated with neurodeveopmental disability. He is the elected president of the European association of Perinatal Medicine 2010 – 2012 and serves as Editor of the journal NEONATOLOGY.

 

Contact

Universitätsklinikum Würzburg

Josef-Schneider-Str. 2
97080 Würzburg
GERMANY

www.uk-wuerzburg.de

 



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Funded by the European Commisssion under the grant agreement n° HEALTH-F2-2009-241778.